Note that morrison and mosher explicitly specified equality between optical rotation and enantiomer composition, meaning that op ee. Stereoisomerie en chimie organique sciences mont blanc. A monounsaturated metabolite, e2ene vpa, is at least as potent as the parent drug vpa in several animal models of epilepsy. Stereoisomerie, enantiomeres, diastereoisomeres youtube. The presumed equality between ee and the earlier term op was, of course. Moreover, e2ene vpa appears to be free of two serious side effects of. To verify that your answers are correct, look in your textbook at the end of chapter 5. Valproic acid vpa is a broad spectrum antiepileptic agent used widely in the treatment of absence and tonicclonic seizures. Vpa is extensively metabolized and forms 17 metabolites in man. Le substituant terminal ayant le plus haut degre doxydation cho ou cor est toujours situe a. This is the way i remembered it when i first came across ez notation. Pdf functional interaction between local anaesthetics. Electrophysiological studies with bupivacaine and nifedipine.
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